OLD EGGS FOR NEW – DOES THE ADULT MAMMALIAN OVARY EVER MAKE DE NOVO OOCYTES? Aims/Objectives: Reproductive biology is a vast and ever expanding field and within it, the possibility of female germline stem cells in the adult mammalian ovary
ثبت نشده
چکیده
Aims/Objectives: Reproductive biology is a vast and ever expanding field and within it, the possibility of female germline stem cells in the adult mammalian ovary has become the subject de jour. These cells – defined as “a unique cell population committed to producing gametes for the propagation of the species” – could hold the key to allowing women who have had fertility problems to become pregnant.
منابع مشابه
P-70: Evidence for Differential Gene Expression of A Major EpigeneticModifier Enzyme, de novo DNA Methyltransferase 3b, through Vitrification of Mouse Ovary Tissue
Background: Ovarian tissue cryopreservation is a feasible method to preserve female reproductive potential, especially in young patients with cancer or in women at risk of premature ovarian failure. Vitrification has recently emerged as a new trend for biological specimen preservation. On the other hand, gene expression that changes during vitrification can influence oocyte maturation and need ...
متن کاملGerm stem cells in the mammalian adult ovary: considerations by a fan of the primordial germ cells.
At or early after birth, mammalian ovaries are filled with primordial follicles each composed by an oocyte blocked at the end of prophase I surrounded by a single layer of granulosa cells. The doctrine that female mammals are born with a finite number of oocytes fated to be exhausted with the age has been challenged by recent results claiming that new oocytes can be continuously formed in the p...
متن کاملP-217: The Effect of Progesterone on The In Vitro Maturation of Mouse Germinal Vesicle Oocytes Derived from Polycystic Ovary
Background: Polycystic ovary syndrome (PCOS) is characterized by chronic anovulation and hyperandro genism and affects approximately 5-10% of women of reproductive age. In vitro maturation (IVM) of mammalian oocytes has become an efficient method to produce mature oocytes in order to use in assisted reproductive techniques such as in vitro fertilization (IVF), intra cytoplasmic sperm injection ...
متن کاملCan ovarian infertility be treated with bone marrow- or ovary-derived germ cells?
A year ago, reproductive biologists and general public were astonished with evidence reported by Johnson et al. in Nature 428:145 that mammalian ovaries possess persisting large germline stem cells, which allegedly enable follicular renewal in adult females. Recently, the same research group declared such view obscure, and reported that mammalian oocytes originate from putative germ cells in bo...
متن کاملDev125211 2554..2563
The adult mammalian ovary is devoid of definitive germline stem cells. As such, female reproductive senescence largely results from the depletion of a finite ovarian follicle pool that is produced during embryonic development. Remarkably, the crucial nature and regulation of follicle assembly and survival during embryogenesis is just coming into focus. This developmental pathway involves the co...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2014